ABSTRACT
Traditional herbal healers "Hakims" use various plants of the Cholistan desert, Pakistan for treating a number of infectious and non-infectious diseases. However, there has never been a scientific validation of these plant-based therapeutics. We compared the antipyretic effect of Echinops echinatus, Alhagi maurorum, Fagonia cretica, Cymbopogon jwarancusa and Panicum turgidum in animal model. These plants were used to reduce E.coli lysate induced pyrexia in rabbits. There were five groups of rabbits having five rabbits in each group. Among these five groups, three received various doses of experimental treatment, paracetamol was given to fourth group known as positive control. The fifth group of animals served as negative control and received no treatment. Ethanol extracts of Fagonia cretica [500mg/kg], Panicum turgidum [500mg/kg and 750mg/kg], Alhagi maurorum [500 and 750mg/kg], Cymbopogon jwarancusa [250mg/kg] and Echinops echinatus [750mg/kg] showed significant antipyretic effects when compared with controls and experimental counterparts. These results revealed that ethanol extracts of the plants evaluated in this study have dose dependent antipyretic activity. Further detailed screening of these plant species is recommended
Subject(s)
Animals , Antipyretics , Rabbits , Plant Extracts , Escherichia coliABSTRACT
Pyrexia and inflammation are indicatives of various disorders. Modern medicines are available for treatment of pyrexia, but they have few side effects. Several studies are ongoing Worldwide to search natural antipyretic agents with better efficacy and fewer or no side effects. This study was aimed at evaluating the antipyretic activity of Moringa oleifera bark in rabbits against E. coli induced pyrexia. Rectal temperature was recorded with digital thermometer at 0 h and E.coli suspension was injected. After 1 h again rectal temperature of the animals was recorded and hydro-alcoholic extract were administered to the treatment groups and paracetamol hydro-alcoholic 50 mg/kg orally to the positive control group. Then rectal temperature was recorded at the interval of one h for 4 h. After the drug administration [at h 1], the decrease in body temperature with the dose of 25mg/kg[-1] during next four h ranged between 1.9-2.6 [degree sign]F as compared to the negative control. At the dose of 50mg/kg[-1] the decrease in temperature was 1.9-3.0 [degree sign]F. The decrease in body temperature at the dose of 100mg/kg[-1] was high, which ranged from 2.3-3.1oF as compared to negative control. Paracetamol, a standard drug, also significantly lowered the temperature but Moringa oleifera at the concentration of 100mg/kg[-1] lowered the body temperature significantly as compared to the negative as well as positive control. Moringa oleifera bark has marked antipyretic activity in animal models and this strongly supports the ethnopharmacological uses of Moringa oleifera bark as an antipyretic plant
ABSTRACT
A retrospective analysis of the laboratory results was performed to explore the turnaround time [TAT] for the laboratory services. The TAT for specimens arriving at the main laboratory from wards, main laboratory and critical care areas was noted and compared with the standard set for reporting. Median TAT for results of 169 blood samples was on average 195 min [n=170], 172 min [n=169], 121 min [n=167] from main lab, wards and for STAT samples from critical care areas respectively. Median analytical time was 170 min, 105 min, and 72 min from main lab, from wards and for STAT samples respectively. This TAT is within acceptable limits according to the standard sets. However, high transport time from critical care areas [median 49 min] was noted, which can be further improved if the portering and transport arrangements of the specimens are made more effective